diff --git a/src/dec/vp8_dec.c b/src/dec/vp8_dec.c
index 6212efd1..c904b529 100644
--- a/src/dec/vp8_dec.c
+++ b/src/dec/vp8_dec.c
@@ -491,7 +491,7 @@ static int GetCoeffsAlt(VP8BitReader* const br,
   return 16;
 }
 
-WEBP_TSAN_IGNORE_FUNCTION static void InitGetCoeffs(void) {
+static WEBP_TSAN_IGNORE_FUNCTION void InitGetCoeffs(void) {
   if (GetCoeffs == NULL) {
     if (VP8GetCPUInfo != NULL && VP8GetCPUInfo(kSlowSSSE3)) {
       GetCoeffs = GetCoeffsAlt;
diff --git a/src/dsp/alpha_processing.c b/src/dsp/alpha_processing.c
index 995b4345..819d1391 100644
--- a/src/dsp/alpha_processing.c
+++ b/src/dsp/alpha_processing.c
@@ -409,12 +409,7 @@ extern void WebPInitAlphaProcessingSSE2(void);
 extern void WebPInitAlphaProcessingSSE41(void);
 extern void WebPInitAlphaProcessingNEON(void);
 
-static volatile VP8CPUInfo alpha_processing_last_cpuinfo_used =
-    (VP8CPUInfo)&alpha_processing_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void WebPInitAlphaProcessing(void) {
-  if (alpha_processing_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(WebPInitAlphaProcessing) {
   WebPMultARGBRow = WebPMultARGBRow_C;
   WebPMultRow = WebPMultRow_C;
   WebPApplyAlphaMultiply4444 = ApplyAlphaMultiply_16b_C;
@@ -474,6 +469,4 @@ WEBP_TSAN_IGNORE_FUNCTION void WebPInitAlphaProcessing(void) {
   assert(WebPPackRGB != NULL);
   assert(WebPHasAlpha8b != NULL);
   assert(WebPHasAlpha32b != NULL);
-
-  alpha_processing_last_cpuinfo_used = VP8GetCPUInfo;
 }
diff --git a/src/dsp/cost.c b/src/dsp/cost.c
index a732389d..634ccc20 100644
--- a/src/dsp/cost.c
+++ b/src/dsp/cost.c
@@ -378,12 +378,7 @@ extern void VP8EncDspCostInitMIPS32(void);
 extern void VP8EncDspCostInitMIPSdspR2(void);
 extern void VP8EncDspCostInitSSE2(void);
 
-static volatile VP8CPUInfo cost_last_cpuinfo_used =
-    (VP8CPUInfo)&cost_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void VP8EncDspCostInit(void) {
-  if (cost_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(VP8EncDspCostInit) {
   VP8GetResidualCost = GetResidualCost_C;
   VP8SetResidualCoeffs = SetResidualCoeffs_C;
 
@@ -405,8 +400,6 @@ WEBP_TSAN_IGNORE_FUNCTION void VP8EncDspCostInit(void) {
     }
 #endif
   }
-
-  cost_last_cpuinfo_used = VP8GetCPUInfo;
 }
 
 //------------------------------------------------------------------------------
diff --git a/src/dsp/dec.c b/src/dsp/dec.c
index 7e824075..1119842d 100644
--- a/src/dsp/dec.c
+++ b/src/dsp/dec.c
@@ -741,12 +741,7 @@ extern void VP8DspInitMIPS32(void);
 extern void VP8DspInitMIPSdspR2(void);
 extern void VP8DspInitMSA(void);
 
-static volatile VP8CPUInfo dec_last_cpuinfo_used =
-    (VP8CPUInfo)&dec_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void VP8DspInit(void) {
-  if (dec_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(VP8DspInit) {
   VP8InitClipTables();
 
 #if !WEBP_NEON_OMIT_C_CODE
@@ -889,6 +884,4 @@ WEBP_TSAN_IGNORE_FUNCTION void VP8DspInit(void) {
   assert(VP8PredChroma8[5] != NULL);
   assert(VP8PredChroma8[6] != NULL);
   assert(VP8DitherCombine8x8 != NULL);
-
-  dec_last_cpuinfo_used = VP8GetCPUInfo;
 }
diff --git a/src/dsp/dsp.h b/src/dsp/dsp.h
index 5146949e..4ab77a51 100644
--- a/src/dsp/dsp.h
+++ b/src/dsp/dsp.h
@@ -141,6 +141,42 @@ extern "C" {
 #endif
 #endif
 
+#if defined(WEBP_USE_THREAD) && !defined(_WIN32)
+#include <pthread.h>  // NOLINT
+
+#define WEBP_DSP_INIT(func) do {                                    \
+  static volatile VP8CPUInfo func ## _last_cpuinfo_used =           \
+      (VP8CPUInfo)&func ## _last_cpuinfo_used;                      \
+  static pthread_mutex_t func ## _lock = PTHREAD_MUTEX_INITIALIZER; \
+  if (pthread_mutex_lock(&func ## _lock)) break;                    \
+  if (func ## _last_cpuinfo_used != VP8GetCPUInfo) func();          \
+  func ## _last_cpuinfo_used = VP8GetCPUInfo;                       \
+  (void)pthread_mutex_unlock(&func ## _lock);                       \
+} while (0)
+#else  // !(defined(WEBP_USE_THREAD) && !defined(_WIN32))
+#define WEBP_DSP_INIT(func) do {                                    \
+  static volatile VP8CPUInfo func ## _last_cpuinfo_used =           \
+      (VP8CPUInfo)&func ## _last_cpuinfo_used;                      \
+  if (func ## _last_cpuinfo_used == VP8GetCPUInfo) break;           \
+  func();                                                           \
+  func ## _last_cpuinfo_used = VP8GetCPUInfo;                       \
+} while (0)
+#endif  // defined(WEBP_USE_THREAD) && !defined(_WIN32)
+
+// Defines an Init + helper function that control multiple initialization of
+// function pointers / tables.
+/* Usage:
+   WEBP_DSP_INIT_FUNC(InitFunc) {
+     ...function body
+   }
+*/
+#define WEBP_DSP_INIT_FUNC(name)                             \
+  static WEBP_TSAN_IGNORE_FUNCTION void name ## _body(void); \
+  WEBP_TSAN_IGNORE_FUNCTION void name(void) {                \
+    WEBP_DSP_INIT(name ## _body);                            \
+  }                                                          \
+  static WEBP_TSAN_IGNORE_FUNCTION void name ## _body(void)
+
 #define WEBP_UBSAN_IGNORE_UNDEF
 #define WEBP_UBSAN_IGNORE_UNSIGNED_OVERFLOW
 #if defined(__clang__) && defined(__has_attribute)
@@ -196,7 +232,7 @@ WEBP_EXTERN VP8CPUInfo VP8GetCPUInfo;
 // avoiding a compiler warning.
 #define WEBP_DSP_INIT_STUB(func) \
   extern void func(void); \
-  WEBP_TSAN_IGNORE_FUNCTION void func(void) {}
+  void func(void) {}
 
 //------------------------------------------------------------------------------
 // Encoding
diff --git a/src/dsp/enc.c b/src/dsp/enc.c
index 1c807f1d..fa23b40a 100644
--- a/src/dsp/enc.c
+++ b/src/dsp/enc.c
@@ -740,12 +740,7 @@ extern void VP8EncDspInitMIPS32(void);
 extern void VP8EncDspInitMIPSdspR2(void);
 extern void VP8EncDspInitMSA(void);
 
-static volatile VP8CPUInfo enc_last_cpuinfo_used =
-    (VP8CPUInfo)&enc_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void VP8EncDspInit(void) {
-  if (enc_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(VP8EncDspInit) {
   VP8DspInit();  // common inverse transforms
   InitTables();
 
@@ -838,6 +833,4 @@ WEBP_TSAN_IGNORE_FUNCTION void VP8EncDspInit(void) {
   assert(VP8EncQuantizeBlockWHT != NULL);
   assert(VP8Copy4x4 != NULL);
   assert(VP8Copy16x8 != NULL);
-
-  enc_last_cpuinfo_used = VP8GetCPUInfo;
 }
diff --git a/src/dsp/filters.c b/src/dsp/filters.c
index ca5f877d..069a22ea 100644
--- a/src/dsp/filters.c
+++ b/src/dsp/filters.c
@@ -238,12 +238,7 @@ extern void VP8FiltersInitMSA(void);
 extern void VP8FiltersInitNEON(void);
 extern void VP8FiltersInitSSE2(void);
 
-static volatile VP8CPUInfo filters_last_cpuinfo_used =
-    (VP8CPUInfo)&filters_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void VP8FiltersInit(void) {
-  if (filters_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(VP8FiltersInit) {
   WebPUnfilters[WEBP_FILTER_NONE] = NULL;
 #if !WEBP_NEON_OMIT_C_CODE
   WebPUnfilters[WEBP_FILTER_HORIZONTAL] = HorizontalUnfilter_C;
@@ -289,6 +284,4 @@ WEBP_TSAN_IGNORE_FUNCTION void VP8FiltersInit(void) {
   assert(WebPFilters[WEBP_FILTER_HORIZONTAL] != NULL);
   assert(WebPFilters[WEBP_FILTER_VERTICAL] != NULL);
   assert(WebPFilters[WEBP_FILTER_GRADIENT] != NULL);
-
-  filters_last_cpuinfo_used = VP8GetCPUInfo;
 }
diff --git a/src/dsp/lossless.c b/src/dsp/lossless.c
index 83f553d9..f9b3c182 100644
--- a/src/dsp/lossless.c
+++ b/src/dsp/lossless.c
@@ -577,9 +577,6 @@ extern void VP8LDspInitNEON(void);
 extern void VP8LDspInitMIPSdspR2(void);
 extern void VP8LDspInitMSA(void);
 
-static volatile VP8CPUInfo lossless_last_cpuinfo_used =
-    (VP8CPUInfo)&lossless_last_cpuinfo_used;
-
 #define COPY_PREDICTOR_ARRAY(IN, OUT) do {                \
   (OUT)[0] = IN##0_C;                                     \
   (OUT)[1] = IN##1_C;                                     \
@@ -599,9 +596,7 @@ static volatile VP8CPUInfo lossless_last_cpuinfo_used =
   (OUT)[15] = IN##0_C;                                    \
 } while (0);
 
-WEBP_TSAN_IGNORE_FUNCTION void VP8LDspInit(void) {
-  if (lossless_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(VP8LDspInit) {
   COPY_PREDICTOR_ARRAY(Predictor, VP8LPredictors)
   COPY_PREDICTOR_ARRAY(Predictor, VP8LPredictors_C)
   COPY_PREDICTOR_ARRAY(PredictorAdd, VP8LPredictorsAdd)
@@ -658,8 +653,6 @@ WEBP_TSAN_IGNORE_FUNCTION void VP8LDspInit(void) {
   assert(VP8LConvertBGRAToRGB565 != NULL);
   assert(VP8LMapColor32b != NULL);
   assert(VP8LMapColor8b != NULL);
-
-  lossless_last_cpuinfo_used = VP8GetCPUInfo;
 }
 #undef COPY_PREDICTOR_ARRAY
 
diff --git a/src/dsp/lossless_enc.c b/src/dsp/lossless_enc.c
index 92ca3c05..d608326f 100644
--- a/src/dsp/lossless_enc.c
+++ b/src/dsp/lossless_enc.c
@@ -863,12 +863,7 @@ extern void VP8LEncDspInitMIPS32(void);
 extern void VP8LEncDspInitMIPSdspR2(void);
 extern void VP8LEncDspInitMSA(void);
 
-static volatile VP8CPUInfo lossless_enc_last_cpuinfo_used =
-    (VP8CPUInfo)&lossless_enc_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void VP8LEncDspInit(void) {
-  if (lossless_enc_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(VP8LEncDspInit) {
   VP8LDspInit();
 
 #if !WEBP_NEON_OMIT_C_CODE
@@ -1011,8 +1006,6 @@ WEBP_TSAN_IGNORE_FUNCTION void VP8LEncDspInit(void) {
   assert(VP8LPredictorsSub_C[13] != NULL);
   assert(VP8LPredictorsSub_C[14] != NULL);
   assert(VP8LPredictorsSub_C[15] != NULL);
-
-  lossless_enc_last_cpuinfo_used = VP8GetCPUInfo;
 }
 
 //------------------------------------------------------------------------------
diff --git a/src/dsp/rescaler.c b/src/dsp/rescaler.c
index 4b6b7834..f307d350 100644
--- a/src/dsp/rescaler.c
+++ b/src/dsp/rescaler.c
@@ -204,11 +204,7 @@ extern void WebPRescalerDspInitMIPSdspR2(void);
 extern void WebPRescalerDspInitMSA(void);
 extern void WebPRescalerDspInitNEON(void);
 
-static volatile VP8CPUInfo rescaler_last_cpuinfo_used =
-    (VP8CPUInfo)&rescaler_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void WebPRescalerDspInit(void) {
-  if (rescaler_last_cpuinfo_used == VP8GetCPUInfo) return;
+WEBP_DSP_INIT_FUNC(WebPRescalerDspInit) {
 #if !defined(WEBP_REDUCE_SIZE)
 #if !WEBP_NEON_OMIT_C_CODE
   WebPRescalerExportRowExpand = WebPRescalerExportRowExpand_C;
@@ -253,5 +249,4 @@ WEBP_TSAN_IGNORE_FUNCTION void WebPRescalerDspInit(void) {
   assert(WebPRescalerImportRowExpand != NULL);
   assert(WebPRescalerImportRowShrink != NULL);
 #endif   // WEBP_REDUCE_SIZE
-  rescaler_last_cpuinfo_used = VP8GetCPUInfo;
 }
diff --git a/src/dsp/ssim.c b/src/dsp/ssim.c
index dc1b518a..989ce825 100644
--- a/src/dsp/ssim.c
+++ b/src/dsp/ssim.c
@@ -139,12 +139,7 @@ VP8AccumulateSSEFunc VP8AccumulateSSE;
 
 extern void VP8SSIMDspInitSSE2(void);
 
-static volatile VP8CPUInfo ssim_last_cpuinfo_used =
-    (VP8CPUInfo)&ssim_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void VP8SSIMDspInit(void) {
-  if (ssim_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(VP8SSIMDspInit) {
 #if !defined(WEBP_REDUCE_SIZE)
   VP8SSIMGetClipped = SSIMGetClipped_C;
   VP8SSIMGet = SSIMGet_C;
@@ -161,6 +156,4 @@ WEBP_TSAN_IGNORE_FUNCTION void VP8SSIMDspInit(void) {
     }
 #endif
   }
-
-  ssim_last_cpuinfo_used = VP8GetCPUInfo;
 }
diff --git a/src/dsp/upsampling.c b/src/dsp/upsampling.c
index ddfd1925..9b60da5b 100644
--- a/src/dsp/upsampling.c
+++ b/src/dsp/upsampling.c
@@ -219,12 +219,7 @@ extern void WebPInitYUV444ConvertersMIPSdspR2(void);
 extern void WebPInitYUV444ConvertersSSE2(void);
 extern void WebPInitYUV444ConvertersSSE41(void);
 
-static volatile VP8CPUInfo upsampling_last_cpuinfo_used1 =
-    (VP8CPUInfo)&upsampling_last_cpuinfo_used1;
-
-WEBP_TSAN_IGNORE_FUNCTION void WebPInitYUV444Converters(void) {
-  if (upsampling_last_cpuinfo_used1 == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(WebPInitYUV444Converters) {
   WebPYUV444Converters[MODE_RGBA]      = WebPYuv444ToRgba_C;
   WebPYUV444Converters[MODE_BGRA]      = WebPYuv444ToBgra_C;
   WebPYUV444Converters[MODE_RGB]       = WebPYuv444ToRgb_C;
@@ -254,7 +249,6 @@ WEBP_TSAN_IGNORE_FUNCTION void WebPInitYUV444Converters(void) {
     }
 #endif
   }
-  upsampling_last_cpuinfo_used1 = VP8GetCPUInfo;
 }
 
 //------------------------------------------------------------------------------
@@ -266,12 +260,7 @@ extern void WebPInitUpsamplersNEON(void);
 extern void WebPInitUpsamplersMIPSdspR2(void);
 extern void WebPInitUpsamplersMSA(void);
 
-static volatile VP8CPUInfo upsampling_last_cpuinfo_used2 =
-    (VP8CPUInfo)&upsampling_last_cpuinfo_used2;
-
-WEBP_TSAN_IGNORE_FUNCTION void WebPInitUpsamplers(void) {
-  if (upsampling_last_cpuinfo_used2 == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(WebPInitUpsamplers) {
 #ifdef FANCY_UPSAMPLING
 #if !WEBP_NEON_OMIT_C_CODE
   WebPUpsamplers[MODE_RGBA]      = UpsampleRgbaLinePair_C;
@@ -333,7 +322,6 @@ WEBP_TSAN_IGNORE_FUNCTION void WebPInitUpsamplers(void) {
 #endif
 
 #endif  // FANCY_UPSAMPLING
-  upsampling_last_cpuinfo_used2 = VP8GetCPUInfo;
 }
 
 //------------------------------------------------------------------------------
diff --git a/src/dsp/yuv.c b/src/dsp/yuv.c
index 957d1d66..14e67fc2 100644
--- a/src/dsp/yuv.c
+++ b/src/dsp/yuv.c
@@ -75,12 +75,7 @@ extern void WebPInitSamplersSSE41(void);
 extern void WebPInitSamplersMIPS32(void);
 extern void WebPInitSamplersMIPSdspR2(void);
 
-static volatile VP8CPUInfo yuv_last_cpuinfo_used =
-    (VP8CPUInfo)&yuv_last_cpuinfo_used;
-
-WEBP_TSAN_IGNORE_FUNCTION void WebPInitSamplers(void) {
-  if (yuv_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(WebPInitSamplers) {
   WebPSamplers[MODE_RGB]       = YuvToRgbRow;
   WebPSamplers[MODE_RGBA]      = YuvToRgbaRow;
   WebPSamplers[MODE_BGR]       = YuvToBgrRow;
@@ -116,7 +111,6 @@ WEBP_TSAN_IGNORE_FUNCTION void WebPInitSamplers(void) {
     }
 #endif  // WEBP_USE_MIPS_DSP_R2
   }
-  yuv_last_cpuinfo_used = VP8GetCPUInfo;
 }
 
 //-----------------------------------------------------------------------------
@@ -260,18 +254,13 @@ void (*WebPSharpYUVUpdateRGB)(const int16_t* ref, const int16_t* src,
 void (*WebPSharpYUVFilterRow)(const int16_t* A, const int16_t* B, int len,
                               const uint16_t* best_y, uint16_t* out);
 
-static volatile VP8CPUInfo rgba_to_yuv_last_cpuinfo_used =
-    (VP8CPUInfo)&rgba_to_yuv_last_cpuinfo_used;
-
 extern void WebPInitConvertARGBToYUVSSE2(void);
 extern void WebPInitConvertARGBToYUVSSE41(void);
 extern void WebPInitConvertARGBToYUVNEON(void);
 extern void WebPInitSharpYUVSSE2(void);
 extern void WebPInitSharpYUVNEON(void);
 
-WEBP_TSAN_IGNORE_FUNCTION void WebPInitConvertARGBToYUV(void) {
-  if (rgba_to_yuv_last_cpuinfo_used == VP8GetCPUInfo) return;
-
+WEBP_DSP_INIT_FUNC(WebPInitConvertARGBToYUV) {
   WebPConvertARGBToY = ConvertARGBToY_C;
   WebPConvertARGBToUV = WebPConvertARGBToUV_C;
 
@@ -316,6 +305,4 @@ WEBP_TSAN_IGNORE_FUNCTION void WebPInitConvertARGBToYUV(void) {
   assert(WebPSharpYUVUpdateY != NULL);
   assert(WebPSharpYUVUpdateRGB != NULL);
   assert(WebPSharpYUVFilterRow != NULL);
-
-  rgba_to_yuv_last_cpuinfo_used = VP8GetCPUInfo;
 }
diff --git a/src/enc/near_lossless_enc.c b/src/enc/near_lossless_enc.c
index cadd14c6..5517a7e2 100644
--- a/src/enc/near_lossless_enc.c
+++ b/src/enc/near_lossless_enc.c
@@ -146,6 +146,6 @@ int VP8ApplyNearLossless(const WebPPicture* const picture, int quality,
 
 // Define a stub to suppress compiler warnings.
 extern void VP8LNearLosslessStub(void);
-WEBP_TSAN_IGNORE_FUNCTION void VP8LNearLosslessStub(void) {}
+void VP8LNearLosslessStub(void) {}
 
 #endif  // (WEBP_NEAR_LOSSLESS == 1)
diff --git a/src/enc/picture_csp_enc.c b/src/enc/picture_csp_enc.c
index d6dbae62..02d9df76 100644
--- a/src/enc/picture_csp_enc.c
+++ b/src/enc/picture_csp_enc.c
@@ -126,7 +126,7 @@ static WEBP_INLINE int LinearToGamma(uint32_t base_value, int shift) {
 
 #else
 
-static WEBP_TSAN_IGNORE_FUNCTION void InitGammaTables(void) {}
+static void InitGammaTables(void) {}
 static WEBP_INLINE uint32_t GammaToLinear(uint8_t v) { return v; }
 static WEBP_INLINE int LinearToGamma(uint32_t base_value, int shift) {
   return (int)(base_value << shift);
@@ -238,7 +238,7 @@ static WEBP_INLINE uint32_t LinearToGammaS(uint32_t value) {
 
 #else
 
-static WEBP_TSAN_IGNORE_FUNCTION void InitGammaTablesS(void) {}
+static void InitGammaTablesS(void) {}
 static WEBP_INLINE uint32_t GammaToLinearS(int v) {
   return (v << GAMMA_TO_LINEAR_BITS) / MAX_Y_T;
 }